Section 13
Chapter 12,167

IGF-I and vasoactive intestinal peptide (VIP) regulate cAMP-response element-binding protein (CREB) -dependent transcription via the mitogen-activated protein kinase (MAPK) pathway in pituitary cells: requirement of Rap1

Fernández, M.; Sánchez-Franco, F.; Palacios, N.; Sánchez, I.; Cacicedo, L.

Journal of Molecular Endocrinology 34(3): 699-712


ISSN/ISBN: 0952-5041
PMID: 15956341
DOI: 10.1677/jme.1.01703
Accession: 012166613

In previous studies we demonstrated that vasoactive intestinal peptide (VIP) mediation, and interactions between mitogen-activated protein kinase (MAPK) and cAMP/protein kinase A (PKA) signaling pathways are implicated in insulin-like growth factor I (IGF-I)- and VIP-induced lactotroph proliferation. These facts led us to investigate the intracellular mechanisms involved in IGF-1- and VIP-induced lactotroph proliferation.

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