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Identification of SpyA, a novel ADP-ribosyltransferase of Streptococcus pyogenes

Identification of SpyA, a novel ADP-ribosyltransferase of Streptococcus pyogenes

Molecular Microbiology 54(1): 89-98

Streptococcus pyogenes, the aetiological agent of both respiratory and skin infections, produces numerous exotoxins to establish infection. This report identifies a new exotoxin produced by this organism, termed SpyA, for S. py ogenes DP-ribosylating toxin. SpyA, MW 24.9, has amino acid identity with the ADP-riboslytransferases (ADPRTs) Staphylococcus aureus EDIN and Clostridium botulinum C3.

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Accession: 012170278

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PMID: 15458407

DOI: 10.1111/j.1365-2958.2004.04262.x

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