Section 13
Chapter 12,190

Improving nature's enzyme active site with genetically encoded unnatural amino acids

Jackson, J.C.; Duffy, S.P.; Hess, K.R.; Mehl, R.A.

Journal of the American Chemical Society 128(34): 11124-11127


ISSN/ISBN: 0002-7863
PMID: 16925430
DOI: 10.1021/ja061099y
Accession: 012189267

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The ability to site-specifically incorporate a diverse set of unnatural amino acids (> 30) into proteins and quickly add new structures of interest has recently changed our approach to protein use and study. One important question yet unaddressed with unnatural amino acids ( UAAs) is whether they can improve the activity of an enzyme beyond that available from the natural 20 amino acids.

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