In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation
Nakagome, K.; Dohi, M.; Okunishi, K.; Komagata, Y.; Nagatani, K.; Tanaka, R.; Miyazaki, J-ichi.; Yamamoto, K.
Journal of Immunology 174(11): 6955-6966
IL-10 is an inummostappressive cytokine. Although previous studies have reported that exogenous delivery of IL-10 reduced airway inflammation in experimental allergic airway inflammation, the mechanism of action has not been fully clarified. In this report, we elucidated a mechanism of action of IL-10 in vivo. BALM mice were immunized and aerosol challenged with OVA-Ag.