+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990



Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990



Radiation Research 160(6): 707-717



An incidence survey of the Life Span Study (LSS) population found 1093 breast cancers among 1059 breast cancer cases diagnosed during 1950-1990. As in earlier breast cancer surveys of this population, a linear and statistically highly significant radiation dose response was found. In the analysis, particular attention was paid to modification of radiation dose response by age at exposure (e) and attained age (a). Dose-specific excess relative risk (ERR(1Sv)) decreased with increasing values of e and a. A linear dose-response model analysis, with e and a as exponential age modifiers, did not conclusively discriminate between the two variables as modifiers of dose response. A modified isotonic regression approach, requiring only that ERR(1Sv) be monotonic in age, provides a fresh perspective indicating that both e and a are important modifiers of dose response. Exposure before age 20 was associated with higher ERR(1Sv) compared to exposure at older ages, with no evidence of consistent variation by exposure age for ages under 20. ERR(1Sv) was observed to decline with increasing attained age, with by far the largest drop around age 35. Possible explanations for these observations are discussed, along with research approaches that might provide more information.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012196747

Download citation: RISBibTeXText

PMID: 14640793

DOI: 10.2307/3580999


Related references

Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1980. Radiation Research 112(2): 243-272, 1987

Incidence of female breast cancer among atomic bomb survivors hiroshima and nagasaki japan 1950 1980. Radiation Research 112(2): 243-272, 1987

Breast cancer incidence among atomic bomb survivors hiroshima and nagasaki 1950 1969. Journal of the National Cancer Institute 59(3): 799-812, 1977

Breast cancer incidence among atomic bomb survivors hiroshima and nagasaki japan 1950 1969. Radiation Research 70(3): 670, 1977

Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. Journal of the National Cancer Institute 62(6): 1347-1359, 1979

Malignant breast tumors among atomic bomb survivors hiroshima and nagasaki japan 1950 1974. Journal of the National Cancer Institute 62(6): 1347-1360, 1979

Cancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies. Radiation Research 137(2 Suppl.): S1-16, 1994

Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiation Research. 138(2): 209-223, 1994

Dose-response relationship of neutrons and gamma rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971. Radiation Research 77(2): 377-394, 1979

Leukemia in atomic bomb survivors hiroshima and nagasaki october 1 1950 september 30 1966. Radiation Research 45(1): 216-233, 1971

Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950--30 September 1966. Radiation Research 45(1): 216-233, 1971

Malignant and benign ovarian neoplasms among atomic bomb survivors, Hiroshima and Nagasaki, 1950-80. Journal of the National Cancer Institute 79(1): 47-57, 1987

Dose response relationship of neutrons and gamma rays to leukemia incidence among atomic bomb survivors in hiroshima and nagasaki japan by type of leukemia 1950 1971. Radiation Research 77(2): 377-394, 1979

Malignant and benign ovarian neoplasms among atomic bomb survivors hiroshima and nagasaki japan 1950 80. JNCI (Journal of the National Cancer Institute) 79(1): 47-58, 1987