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Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples



Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples



Journal of Medical Genetics 42(4): 289-291



Recent case reports have suggested that infertility treatment with intracytoplasmic sperm injection (ICSI) may increase the risk of imprinting defects leading to Angelman syndrome (AS). Although imprinting defects account for only 4% of patients with AS, we have found four cases among 16 AS patients born to subfertile couples, who conceived with or without infertility treatment (25%; relative risk (RR) 6.25; 95% confidence interval (CI) 1.68 to 16.00).

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Accession: 012200001

Download citation: RISBibTeXText

PMID: 15805153

DOI: 10.1136/jmg.2004.026930



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