EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study


Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study



Journal of Clinical Endocrinology and Metabolism 88(11): 5240-5247



ISSN/ISBN: 0021-972X

PMID: 14602756

DOI: 10.1210/jc.2003-030200

The goal of this study was to identify the clinical and biological patterns of hypogonadism in a cohort of 1040 elderly men. Residual androgenic activity was estimated by total testosterone as well as the apparent free testosterone concentration (AFTC) and free testosterone index (FTI) calculated on the basis of concentrations of SHBG and total testosterone using appropriate formulae. The lower limit of the normal range defined by 2 SD below the mean in 150 healthy, nonobese, and nonsmoking men, aged 19-40 yr, was calculated for total testosterone (9.26 nmol/liter), AFTC (146 pmol/liter), and FTI (0.14 nmol/nmol). The prevalence of hypogonadism increased with ageing. Hypogonadal men were older and heavier (due to a higher fat body mass) and had lower concentrations of 17 beta-estradiol and androstenedione than men with normal androgenic activity. Men with decreased AFTC had a slightly lower bone mineral density (BMD) at certain sites. Men with decreased FTI had lower appendicular skeletal muscle mass and relative skeletal muscle index. For all three measures of androgenic activity, hypogonadal men had increased levels of the markers of bone resorption. In the multiple regression models including both 17 beta-estradiol and testosterone (total, AFTC, or FTI), 17 beta-estradiol was the only significant determinant of BMD. In the multiple regression models including 17 beta-estradiol and AFTC or FTI, only testosterone was a significant determinant of the variability in bone formation markers, whereas both 17 beta-estradiol and testosterone were significant determinants of the variability of the markers of bone resorption. Hypogonadism was associated with an increase in the risk of falls, an impairment of static and dynamic balance, as well as the inability to stand up from a chair and to perform the tandem walk. Decreased AFTC (<146 pmol/liter) discriminated best men with functional disabilities (odds ratio, 1.54-7.95; P < 0.05-0.0001). Hypogonadal elderly men had increased bone resorption that was not adequately matched by an increase in bone formation, lower muscle strength, impaired static and dynamic balance, a higher risk of falls, and, in men with low AFTC, a slightly lower BMD. Low AFTC seems to have the best discriminative power for densitometric, biochemical, and functional parameters, followed by FTI, whereas total testosterone was the least discriminative. In multiple regression models, 17 beta-estradiol was the strongest determinant of BMD, and AFTC and FTI were significant determinants of the variability in bone formation markers, whereas both 17 beta-estradiol and testosterone determined the variability in bone resorption markers.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012200243

Download citation: RISBibTeXText

Related references

Increased risk of falls, increased bone resorption and decreased bone mineral density in elderly men with hypogonadism The MINOS Study. Journal of Bone and Mineral Research 17(Suppl 1): S174, 2002

Increased bone resorption is associated with increased risk of cardiovascular events in men: the MINOS study. Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research 24(12): 2023-2031, 2009

Increased bone resorption in moderate smokers The MINOS study. Journal of Bone and Mineral Research 15(Suppl 1): S168, 2000

Increased bone resorption in moderate smokers with low body weight: the Minos study. Journal of Clinical Endocrinology and Metabolism 87(2): 666-674, 2002

Increased bone resorption is associated with higher mortality in community-dwelling men >or=50 years of age: the MINOS study. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 24(6): 1116-1124, 2009

Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women. Proceedings of the Association of American Physicians 109(2): 174-180, 1997

Low width of tubular bones is associated with increased risk of fragility fracture in elderly men--the MINOS study. Bone 38(4): 595-602, 2006

Low width of tubular bones is associated with increased risk of fragility fracture in elderly men - the MINOS study. Bone (New York) 38(4): 595-602, 2006

High bone turnover is associated with accelerated bone loss but not with increased fracture risk in men aged 50 and over: the prospective MINOS study. Annals of the Rheumatic Diseases 67(9): 1249-1255, 2008

Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study. Osteoporosis International: a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa 18(4): 495-503, 2007

In long-term bedridden elderly patients with dietary copper deficiency, biochemical markers of bone resorption are increased with copper supplementation during 12 weeks. Annals of Nutrition and Metabolism 50(5): 420-424, 2006

Increased bone resorption and bone loss in men undergoing medical androgen deprivation therapy for prostate cancer. Journal of Bone and Mineral Research 15(Suppl 1): S298, 2000

Increased bone formation and decreased bone resorption in young x linked hypo phosphatemic mice the cause for the transitory increased metaphyseal bone mass. Calcified Tissue International 33(3): 310, 1981

Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. Journal of Clinical Investigation 110(11): 1643-1650, 2002

The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption. Haemophilia: the Official Journal of the World Federation of Hemophilia 19(6): 908-912, 2013