+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease



Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease



American Journal of Cardiology 95(2): 182-188



Noninvasive stress testing provides prognostic information in patients who have suspected coronary artery disease, but limited data are available on the incremental value of myocardial perfusion testing in high-risk patients. We studied 3,275 patients who underwent cardiac catheterization and single-photon emission computed tomographic (SPECT) perfusion imaging. Median follow-up was 3.1 years for death, cardiovascular death, and a composite of cardiovascular death or nonfatal myocardial infarction. Using Cox's proportional hazards regression models, we examined the relation of SPECT summed stress score (SSS) to each outcome. A 1-unit change in SSS was associated with increased risks of 4%, 7%, and 5% for death, cardiovascular death, and death or nonfatal myocardial infarction, respectively (all p <0.0001). To examine the prognostic utility of SPECT, after baseline adjustments, SSS and angiographic results provided incremental prognostic information for each outcome. Thus, SPECT SSS provides information beyond clinical and angiographic data in patients who have known or suspected coronary artery disease. This information may be useful for stratifying patients into multiple risk categories for future cardiovascular events and potentially guiding therapy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012201166

Download citation: RISBibTeXText

PMID: 15642549

DOI: 10.1016/j.amjcard.2004.09.004


Related references

Incremental prognostic value of adenosine myocardial perfusion single-photon emission computed tomography in women with suspected coronary artery disease. American Journal Of Cardiology. 82(6): 725-730,. 15, 1998

Prognostic Value of Coronary Artery Calcium Scoring in Addition to Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging in Symptomatic Patients. Circulation. Cardiovascular Imaging 9(5):, 2016

Incremental prognostic value of sequential imaging of single-photon emission computed tomography and coronary computed tomography angiography in patients with suspected coronary artery disease. European Heart Journal Cardiovascular Imaging 15(8): 878-885, 2014

Usefulness of stress gated technetium-99m single photon emission computed tomographic myocardial perfusion imaging for the prediction of cardiac death in patients with moderate to severe left ventricular systolic dysfunction and suspected coronary artery disease. American Journal of Cardiology 109(1): 26-30, 2012

Prognostic value of technetium-99m-tetrofosmin stress myocardial perfusion single-photon emission computed tomography in patients with suspected or known coronary artery disease. Journal of Nuclear Medicine 44(5 Suppl.): 3P, 2003

Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease. Journal of the American College of Cardiology 22(3): 665-670, 1993

Comparison of technetium-99m tetrofosmin an thallium-201 single-photon emission computed tomographic imaging for detection of myocardial perfusion defects in patients with coronary artery disease. Journal of the American College of Cardiology 31(2): 331-337, 1998

Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease. Circulation. Cardiovascular Imaging 8(10): E003533, 2015

Usefulness of Stress Gated Technetium-99m Single Photon Emission Computed Tomographic Myocardial Perfusion Imaging for the Prediction of Cardiac Death in Patients With Moderate to Severe Left Ventricular Systolic Dysfunction and Suspected Coronary Artery. 2011

The clinical value of single photon emission computed tomography myocardial perfusion imaging in cardiac risk stratification of very elderly patients ?8 years with suspected coronary artery disease. 2011

The clinical value of single photon emission computed tomography myocardial perfusion imaging in cardiac risk stratification of very elderly patients (≥80 years) with suspected coronary artery disease. Journal of Nuclear Cardiology 19(2): 244-255, 2012

Underestimation of extent and severity of coronary artery disease by dipyridamole stress thallium-201 single-photon emission computed tomographic myocardial perfusion imaging in patients taking antianginal drugs. Journal of the American College of Cardiology 31(7): 1540-1546, 1998

The Incremental Prognostic Value of Cardiac Computed Tomography in Comparison with Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease. Plos one 11(8): E0160188, 2016

Incremental Prognostic Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease. Journal of Atherosclerosis and Thrombosis 22(10): 1040-1050, 2015

Long-term prognostic value of coronary artery calcium scanning, coronary computed tomographic angiography and stress myocardial perfusion imaging in patients with suspected coronary artery disease. Journal of Nuclear Cardiology 25(3): 833-841, 2018