+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status

Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status

Psychopharmacology 189(1): 17-25

Rationale While the personality dimensions of novelty seeking and sensation seeking are associated with drug abuse vulnerability, the mechanisms associated with this vulnerability remain obscure.Objective This study examined the behavioral effects of d-amphetamine in healthy volunteers scoring in the upper and lower quartiles based on age- and gender-adjusted population norms on the impulsive Sensation-Seeking Scale (SSS) of the Zuckerman - Kuhlman personality questionnaire (ZKPQ).Method Participants completed 7-day outpatient studies examining the subjective, performance, and cardiovascular effects of d-amphetamine ( 0, 7.5, and 15 mg/70 kg, p.o.) under double-blind conditions according to a randomized block design. Performance tasks included behavioral measures of impulsivity, including attention, inhibition, and risk-taking behavior.Results No differences in baseline performance or d-amphetamine effects on measures of attention, inhibition, and risk-taking behavior were observed. High impulsive sensation seekers reported greater increases on several subjective report measures associated with drug abuse potential, including visual analog scales feel drug, like drug, and high.Conclusions Healthy adults scoring in the top quartile on the population of the impulsive SSS of the ZKPQ may be vulnerable to the abuse potential of d-amphetamine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012202119

Download citation: RISBibTeXText

PMID: 16972106

DOI: 10.1007/s00213-006-0487-z

Related references

A multivariate assessment of individual differences in sensation seeking and impulsivity as predictors of amphetamine self-administration and prefrontal dopamine function in rats. Experimental and Clinical Psychopharmacology 19(4): 275-284, 2011

Beyond Sensation Seeking: A Conceptual Framework for Individual Differences in Psychostimulant Drug Effects in Healthy Humans. Current Opinion in Behavioral Sciences 13: 63-70, 2017

The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences. Neuropharmacology 47(Suppl. 1): 111-122, 2004

Substance abuse, comorbidity, and sensation seeking: gender differences. Comprehensive Psychiatry 37(6): 384-392, 1996

Individual differences in sensation seeking and attentional ability. Personality and Individual Differences 6(5): 637-639, 1985

Individual differences in vulnerability to drug abuse: the high responders/low responders model. Cns and Neurological Disorders Drug Targets 5(5): 513-520, 2006

Risk taking differences on a behavioral task as a function of potential reward/loss magnitude and individual differences in impulsivity and sensation seeking. Pharmacology Biochemistry and Behavior 93(3): 258-262, 2009

The reinforcing, subject-rated, performance, and cardiovascular effects of d-amphetamine: influence of sensation-seeking status. Addictive Behaviors 32(6): 1177-1188, 2007

Sensation seeking and the endogenous deficit theory of drug abuse. Nida Research Monograph 74: 59-70, 1986

Patterns of drug abuse: relationships with ethnicity, sensation seeking, and anxiety. Journal of Consulting and Clinical Psychology 45(3): 462-468, 1977

Individual differences in embracing negatively valenced art: The roles of openness and sensation seeking. Behavioral and Brain Sciences 40: E360, 2017

Drug abuse patterns, personality characteristics, and relationships with sex, race, and sensation seeking. Journal of Consulting and Clinical Psychology 46(6): 1374-1378, 1978

Food neophobia in humans: effects of manipulated arousal and individual differences in sensation seeking. Physiology & Behavior 61(2): 331-335, 1997

Individual differences in the development of sensation seeking and impulsivity during adolescence: further evidence for a dual systems model. Developmental Psychology 47(3): 739-746, 2011

Individual Differences in Cognitive Control Circuit Anatomy Link Sensation Seeking, Impulsivity, and Substance Use. Journal of Neuroscience 36(14): 4038-4049, 2016