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Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice


Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice



Journal of Immunology 177(5): 3461-3468



ISSN/ISBN: 0022-1767

PMID: 16920988

DOI: 10.4049/jimmunol.177.5.3461

Experimental models reproducing an autoimmune response resulting in skin blistering in immunocompetent animals are lacking. Epidermolysis bullosa acquisita (EBA) is a bullous skin disease caused by autoantibodies to type VII collagen. In this study, we describe an active disease model of EBA by immunizing mice of different strains with murine type VII collagen.

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Accession: 012203887

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