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Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity



Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity



Biomedical and Environmental Sciences 17(3): 315-326



Background/Aim We investigated the relationship between ethanol exposure and heme oxygenase (HO-1) in human hepatocytes in order to ascertain if induction of HO-1 can prevent ethanol induced cellular damage. Methods Dose-dependent (25-100 mmol/L) and time-dependent (0-24 h) ethanol exposure were used in the present study. HO-1 mRNA and protein expression were detected by PT-PCR and Western blot respectively. HO-1 activity was indicated by bilirubin and Fe2+ formation.

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Accession: 012204147

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PMID: 15602829


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