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Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene



Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene



Journal of Immunology 174(7): 4325-4332



Suppressor of cytokine signaling (SOCS1/JAB) has been shown to play an important role in regulating dendritic cell (DC) function and suppressing inflammatory diseases and systemic autoimmunitv. However, role of SOCS1 in DCs for the initiation of Th cell response has not been clarified. Here we demonstrate that SOCSI-deficient DCs induce stronger Th1-type responses both in vitro and in vivo.

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Accession: 012204211

Download citation: RISBibTeXText

PMID: 15778397

DOI: 10.4049/jimmunol.174.7.4325



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