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Inhibition of NF-IL6 activity by manassantin B, a dilignan isolated from Saururus chinensis, in phorbol myristate acetate-stimulated U937 promonocytic cells

Son, K-No.; Song, I-sung.; Shin, Y-Hyun.; Pai, T-Kun.; Chung, D-Kyun.; Baek, N-In.; Lee, J.Joon.; Kim, J.

Molecules and Cells 20(1): 105-111

2005


ISSN/ISBN: 1016-8478
PMID: 16258248
Accession: 012214565

Mannasantin B, a dilignan structurally related to manssantin A, is an inhibitor of NF-kappa B transactivation. In the present study, we found that it inhibited PMA-induced expression of IL-1 beta, IL-1 beta mRNA, and IL-1 beta promoter activity in U937 cells with IC50 values of about 50 nM. It also inhibited NF-IL6- and NF-kappa B-induced activation of IL-1 beta, with IC50 values of 78 nM and 1.6 mu M, respectively, revealing a potent inhibitory effect on NF-IL6.

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