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Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination



Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination



American Journal of Pathology 168(3): 796-804



Infection of the central nervous system (CNS) by the neurotropic JHM strain of mouse hepatitis virus (JHMV) induces an acute encephalomyelitis associated with demyelination. To examine the anti-viral and/or regulatory role of interferon-gamma (IFN-gamma) signaling in the cell that synthesizes and maintains the myelin sheath, we analyzed JHMV pathogenesis in transgenic mice expressing a dominant-negative IFN-gamma receptor on oligodendroglia.

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Accession: 012215914

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PMID: 16507895


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