+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors



Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors



Molecular Cancer Therapeutics 5(4): 1007-1013



The properties of several multitargeted receptor tyrosine kinase inhibitors hive been studied for their inhibition of colony-stimulating factor-1 receptor (CSF-1R) signaling. A structurally novel, multitargeted tyrosine kinase inhibitor (ABT-869), imatinib (STI571), and four compounds currently in clinical development (AG013736, BAY 43-9006, CHIR258, and SU11248) were tested for inhibition of CSF-1R signaling in both the enzymatic and cellular assays.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012216459

Download citation: RISBibTeXText

PMID: 16648572

DOI: 10.1158/1535-7163.mct-05-0359


Related references

Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase. Journal of Biochemistry 151(1): 47-55, 2012

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Molecular Cancer Therapeutics 8(11): 3151-3161, 2009

A point mutation at tyrosine 809 in the human colony stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity association with phosphatidylinositol 3 kinase or induction of c fos and junb genes. Proceedings of the National Academy of Sciences of the United States of America 87(17): 6738-6742, 1990

Tyrosine phosphorylation of MAP kinase, but not ribosomal S6 kinase II, by granulocyte-macrophage colony-stimulating factor. Journal of Leukocyte Biology 0(Suppl. 3): 33, 1992

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proceedings of the National Academy of Sciences of the United States of America 91(8): 2985-2988, 1994

Tyrosine 706 and tyrosine 807 phosphorylation site mutants in the murine colony stimulating factor 1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol 3 kinase but show differential defects in their ability to induce early response gene transcription. Molecular & Cellular Biology 11(9): 4698-4709, 1991

The related adhesion focal tyrosine kinase (RAFTK) is tyrosine phosphorylated and participates in colony-stimulating factor-1/macrophage colony-stimulating factor signaling in monocyte-macrophages. Blood 91(10): 3967-3973, 1998

Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors. Journal of Biological Chemistry 282(6): 4094-4101, 2007

Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt. Journal of Immunology 174(5): 2712-2719, 2005

Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]ĭndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase. Journal of Medicinal Chemistry 42(26): 5464-5474, 1999

Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2- d ]pyrimidines and Pyrimido[5,4- b ]- and -[4,5- b ]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase. Journal of Medicinal Chemistry 42(26): 5464-5474, 1999

Tyrosine kinase inhibitors 16 6,5,6-tricyclic benzothieno pyrimidines and pyrimido - and - indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase. Journal of Medicinal Chemistry 42(26): 5464-5474, 1999

Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor. Journal of Medicinal Chemistry 39(4): 918-928, 1996

Can acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors be overcome by different small-molecule tyrosine kinase inhibitors?. Journal of Clinical Oncology 25(18): 2504-2505, 2007

Inhibition of basic fibroblasts growth factor-mediated tyrosine phosphorylation and protein synthesis by PD 145709, a member of the 2-thioindole class of tyrosine kinase inhibitors. Anti-Cancer Drug Design 10(8): 607-622, 1995