Section 13
Chapter 12,221

Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils

Voyich, J.M.; Braughton, K.R.; Sturdevant, D.E.; Whitney, A.R.; Saïd-Salim, B.; Porcella, S.F.; Long, R.Daniel.; Dorward, D.W.; Gardner, D.J.; Kreiswirth, B.N.; Musser, J.M.; DeLeo, F.R.

Journal of Immunology 175(6): 3907-3919


ISSN/ISBN: 0022-1767
PMID: 16148137
DOI: 10.4049/jimmunol.175.6.3907
Accession: 012220132

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Polymorphonuclear leukocytes (PMNs, or neutrophils) are critical for human innate immunity and kill most invading bacteria. However, pathogens such as Staphylococcus aureus avoid destruction by PMNs to survive, thereby causing human infections. The molecular mechanisms used by pathogens to circumvent killing by the immune system remain largely undefined.

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