Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils
Voyich, J.M.; Braughton, K.R.; Sturdevant, D.E.; Whitney, A.R.; Saïd-Salim, B.; Porcella, S.F.; Long, R.Daniel.; Dorward, D.W.; Gardner, D.J.; Kreiswirth, B.N.; Musser, J.M.; DeLeo, F.R.
Journal of Immunology 175(6): 3907-3919
ISSN/ISBN: 0022-1767 PMID: 16148137 DOI: 10.4049/jimmunol.175.6.3907
Polymorphonuclear leukocytes (PMNs, or neutrophils) are critical for human innate immunity and kill most invading bacteria. However, pathogens such as Staphylococcus aureus avoid destruction by PMNs to survive, thereby causing human infections. The molecular mechanisms used by pathogens to circumvent killing by the immune system remain largely undefined.