Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat
Deng, P-Yue.; Yu, J.; Ye, F.; Li, D.; Luo, D.; Cai, W-Jun.; Zhang, J-Wei.; Luo, X-Gang.; Deng, H-Wu.; Li, Y-Jian.
Journal of Hypertension 23(3): 603-609
ISSN/ISBN: 0263-6352 PMID: 15716703 DOI: 10.1097/01.hjh.0000160218.63726.ec
Background Previous investigations have shown that norepinephrine is capable of inhibiting neurotransmission in capsaicin-sensitive sensory nerves via a prejunctional mechanism. The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats. Methods In the present study, we examined interactions of adrenergic nerves with capsaicin-sensitive sensory nerves in phenol-induced hypertensive rats. Blood pressure, the synthesis and release of calcitonin gene-related peptide (CGRP) and the content of nerve growth factor (NGF) in arteries were determined.