Section 13
Chapter 12,226

Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat

Deng, P-Yue.; Yu, J.; Ye, F.; Li, D.; Luo, D.; Cai, W-Jun.; Zhang, J-Wei.; Luo, X-Gang.; Deng, H-Wu.; Li, Y-Jian.

Journal of Hypertension 23(3): 603-609


ISSN/ISBN: 0263-6352
PMID: 15716703
DOI: 10.1097/01.hjh.0000160218.63726.ec
Accession: 012225717

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Background Previous investigations have shown that norepinephrine is capable of inhibiting neurotransmission in capsaicin-sensitive sensory nerves via a prejunctional mechanism. The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats. Methods In the present study, we examined interactions of adrenergic nerves with capsaicin-sensitive sensory nerves in phenol-induced hypertensive rats. Blood pressure, the synthesis and release of calcitonin gene-related peptide (CGRP) and the content of nerve growth factor (NGF) in arteries were determined.

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