Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine
Federico, L.M.; Naples, M.; Taylor, D.; Adeli, K.
Diabetes 55(5): 1316-1326
2006
ISSN/ISBN: 0012-1797
PMID: 16644688
DOI: 10.2337/db04-1084
Accession: 012229984
Postprandial dyslipidemia is recognized as an important complication of insulin-resistant states, and recent evidence implicates intestinal lipoprotein overproduction as a causative factor. The mechanisms linking intestinal lipoprotein overproduction and aberrant insulin signaling in intestinal enterocytes are currently unknown. Intestinal insulin sensitivity and lipid metabolism were studied in a fructose-fed hamster model of insulin resistance and metabolic dyslipidemia.
PDF emailed within 0-6 h: $19.90
Related References
Federico, L.M.; Naples, M.; Taylor, D.; Adeli, K. 2006: Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia : Εvidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine Diabetes (New York) 55(5): 1316-1326Sajan, M.P.; Standaert, M.L.; Rivas, J.; Miura, A.; Kanoh, Y.; Soto, J.; Taniguchi, C.M.; Kahn, C.R.; Farese, R.V. 2009: Role of atypical protein kinase C in activation of sterol regulatory element binding protein-lc and nuclear factor kappa B (NFKB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance Diabetologia (Berlin) 52(6): 1197-1207
Sajan, M.P.; Standaert, M.L.; Rivas, J.; Miura, A.; Kanoh, Y.; Soto, J.; Taniguchi, C.M.; Kahn, C.R.; Farese, R.V. 2009: Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance Diabetologia 52(6): 1197-1207
Chong, T.; Naples, M.; Federico, L.; Taylor, D.; Smith, G.J.; Cheung, R.C.; Adeli, K. 2006: Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia Atherosclerosis 185(1): 21-31
Bi, Y.; Wu, W.; Shi, J.; Liang, H.; Yin, W.; Chen, Y.; Tang, S.; Cao, S.; Cai, M.; Shen, S.; Gao, Q.; Weng, J.; Zhu, D. 2014: Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription Diabetologia 57(3): 592-602
Taghibiglou, C.; Rashid-Kolvear, F.; Van Iderstine, S.C.; Le-Tien, H.; Fantus, I.G.; Lewis, G.F.; Adeli, K. 2002: Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance Journal of Biological Chemistry 277(1): 793-803
Wu, W.; Tang, S.; Shi, J.; Yin, W.; Cao, S.; Bu, R.; Zhu, D.; Bi, Y. 2015: Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway International Journal of Molecular Medicine 35(6): 1734-1740
Ragheb, R.; Medhat, A.M.; Shanab, G.M.L.; Seoudi, D.M.; Fantus, I.G. 2008: Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance Biochemical and Biophysical Research Communications 370(1): 134-139
Harmancey, R.; Haight, D.L.; Watts, K.A.; Taegtmeyer, H. 2015: Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart Journal of Biological Chemistry 290(52): 30947-30961
Haidari, M.; Leung, N.; Mahbub, F.; Uffelman, K.D.; Kohen-Avramoglu, R.; Lewis, G.F.; Adeli, K. 2002: Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction Journal of Biological Chemistry 277(35): 31646-31655
Kotzka, J.; Müller-Wieland, D. 2004: Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? Expert Opinion on Therapeutic Targets 8(2): 141-149
Shi, K.; Ugi, S.; Shimizu, S.; Sekine, O.; Ikeda, K.; Egawa, K.; Yoshizaki, T.; Nagai, Y.; Nishio, Y.; Takada, T.; Torii, R.; Kimura, H.; Kashiwagi, A.; Maegawa, H. 2007: Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression Biochemical and Biophysical Research Communications 363(3): 626-632
Nieminen, T.; Matinheikki, J.; Nenonen, A.; Kukkonen-Harjula, K.; Lindi, V.; Hämelahti, Päivi.; Laaksonen, R.; Fan, Y-Mei.; Kähönen, M.; Fogelholm, M.; Lehtimäki, T. 2007: The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction Metabolism, Clinical and Experimental 56(7): 876-880
Nikpour, P.; Miranzadeh-Mahabadi, H.; Emadi-Baygi, M.; Kelishadi, R. 2014: Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance Journal of Pediatric Endocrinology and Metabolism: Jpem 27(7-8): 611-615
Ugi, S.; Shi, K.; Nishio, Y.; Shimizu, S.; Guo, B.; Sekine, O.; Ikeda, K.; Egawa, K.; Yoshizaki, T.; Nagai, Y.; Koya, D.; Takada, T.; Torii, R.; Kimura, H.; Kashiwagi, A.; Maegawa, H. 2009: Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia Journal of Biochemistry 146(4): 541-547
Du, X.; Cai, C.; Yao, J.; Zhou, Y.; Yu, H.; Shen, W. 2017: Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD Biochemical and Biophysical Research Communications 483(1): 409-417
Laudes, M.; Barroso, I.ês.; Luan, J.'a.; Soos, M.A.; Yeo, G.; Meirhaeghe, A.; Logie, L.; Vidal-Puig, A.; Schafer, A.J.; Wareham, N.J.; O'Rahilly, S. 2004: Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes Diabetes 53(3): 842-846
Yahagi, N.; Shimano, H.; Hasty, A.H.; Matsuzaka, T.; Ide, T.; Yoshikawa, T.; Amemiya-Kudo, M.; Tomita, S.; Okazaki, H.; Tamura, Y.; Iizuka, Y.; Ohashi, K.; Osuga, J-Ichi.; Harada, K.; Gotoda, T.; Nagai, R.; Ishibashi, S.; Yamada, N. 2002: Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice Journal of Biological Chemistry 277(22): 19353-19357
Yamamoto, T.; Watanabe, K.; Inoue, N.; Nakagawa, Y.; Ishigaki, N.; Matsuzaka, T.; Takeuchi, Y.; Kobayashi, K.; Yatoh, S.; Takahashi, A.; Suzuki, H.; Yahagi, N.; Gotoda, T.; Yamada, N.; Shimano, H. 2010: Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin Journal of Lipid Research 51(7): 1859-1870
Wu, W.; Bi, Y.; Tangsun, Y.; Yin, W.; Chen, Y.; Zhu, D. 2015: Effects of transcription factor sterol regulatory element binding protein-1c in palmitate acid-induced L6 cells insulin resistance and its mechanism Zhonghua Yi Xue Za Zhi 95(8): 611-615