+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Is there an association between angiotensin-converting enzyme gene polymorphism and functional activation of monocytes and macrophage in young patients with essential hypertension?



Is there an association between angiotensin-converting enzyme gene polymorphism and functional activation of monocytes and macrophage in young patients with essential hypertension?



Journal of Hypertension 24(8): 1565-1573



This study was undertaken to determine whether the phenotype of monocytes and monocyte-derived macrophages is more proatherogenic in young persons with arterial hypertension and whether this phenotype is affected by smoking or polymorphism of the angiotensin-converting enzyme (ACE) gene. We enrolled 40 young patients (24.1 +/- 4.7 years) with previously untreated arterial hypertension and 40 age-matched healthy controls. There were 20 smokers and 20 non-smokers in each group. In the hypertensive group, we found enhanced monocyte expression of CD11a (P < 0.001), reduced expression of CD49d (P < 0.001) and CD62L (P < 0.005), greater oxidative stress in resting and phorbol-12-mistrate-13-acetate-stimulated monocytes (P < 0.001), enhanced adhesion of monocytes to endothelial cells (P < 0.001), greater expression of CD36 on monocyte-derived macrophages (P < 0.001), and enhanced production of reactive oxygen species by resting and phorbol-12-mistrate-13-acetate-stimulated macrophages (P < 0.001). Cigarette smoking by hypertensive patients was associated with enhanced (P < 0.002) CD11a expression. There were no associations of ACE gene polymorphism with cellular expression or reactive oxygen species production studied among hypertensive patients. Only CD62L expression in DD homozygote participants was higher (P < 0.039) than in II homozygote participants. It is concluded that arterial hypertension affects the function of monocytes/macrophages in young persons. Polymorphism of the ACE gene is without effect on the functional activation of monocytes and macrophages.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012241307

Download citation: RISBibTeXText

PMID: 16877959

DOI: 10.1097/01.hjh.0000239292.32883.38


Related references

Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and essential hypertension in young Pakistani patients. Journal of Biochemistry and Molecular Biology 37(5): 552-555, 2004

Association of angiotensin I-converting enzyme gene polymorphism with ACE and PAI-1 levels in Guangdong Chinese Han patients with essential hypertension. Nan Fang Yi Ke Da Xue Xue Bao 27(11): 1681-1684, 2007

Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochemical and Biophysical Research Communications 184(1): 9, 1992

Polymorphism of angiotensin I-converting enzyme gene in patients with essential hypertension, left ventricular hypertrophy and myocardial infarction at young age Preliminary study. European Journal of Clinical Pharmacology 52(Suppl. ): A77, 1997

Association of angiotensin I converting enzyme 2 gene polymorphism with essential hypertension in Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22(5): 569-571, 2005

Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene. Journal of Human Genetics 45(5): 294-298, 2000

Angiotensin-converting enzyme gene polymorphism and its association with essential hypertension in a Tibetan population. Hypertension Research 25(3): 481-485, 2002

Lack of association between the I/D polymorphism of the angiotensin-converting enzyme gene and essential hypertension in a Belgian population. Journal of Human Hypertension 8(9): 683-685, 1994

Lack of association of the angiotensin converting enzyme gene polymorphism with essential hypertension in a Chinese population. American Journal Of Hypertension. 10(2): 201, 1997

Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochemical and Biophysical Research Communications 191(2): 399-404, 1993

Angiotensin-converting enzyme gene polymorphism in untreated essential hypertension and response to angiotensin converting enzyme inhibitors. Yaoxue Xuebao 34(9): 655-657, 1999

Association of angiotensin-converting-enzyme gene polymorphism with the depressor response to mild exercise therapy in patients with mild to moderate essential hypertension. Clinical Genetics 62(4): 328-333, 2002

Association of angiotensin converting enzyme (insertion/deletion) gene polymorphism with essential hypertension in northern Indian subjects. Genetic Testing and Molecular Biomarkers 16(3): 174-177, 2012

Gender specific association of insertion/deletion polymorphism of the human angiotensin converting enzyme gene with essential hypertension. International Journal of Human Genetics 4(3): 207-213, 2004

The influence of I/D polymorphism of the angiotensin I converting enzyme (ACE) gene and 4G/5G polymorphism of plasminogen activator inhibitor (PAI-1) gene promoter on the haemostatic system in patients with essential hypertension and dyslipidemia. Annales Academiae Medicae Stetinensis 51(1): 95, 2005