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Isolation and cytokine gene expression of deer mouse peritoneal macrophages



Isolation and cytokine gene expression of deer mouse peritoneal macrophages



BIOS (Ocean Grove) 75(3): 103-108



Deer mice (Peromyscus maniculatus) are the principal reservoir hosts of Sin Nombre hantavirus (SNV). Once infected, deer mice remain persistently infected for the remainder of their lives. It is unknown what immune evasion strategies SNV uses to elude the host immune response, but evidence suggests that macrophages maybe one target of viral infection. If so, SNV may interfere with normal macrophage functions that impair the immune response and contribute to evasion.

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Accession: 012243441

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DOI: 10.2307/4608706


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