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Itraconazole oral solution in treatment of oral candidiasis in 40 patients



Itraconazole oral solution in treatment of oral candidiasis in 40 patients



Zhongguo Xinyao yu Linchuang Zazhi 23(6): 335-338



AIM: To evaluate the efficacy and safety of itraconazole oral solution vs capsule in the treatment of oral candidiasis. METHODS: A total of 78 patients with oral candidiasis confirmed by clinical and mycological methods were enrolled in this study. The patients were randomly divided into treatment group ( treated with itraconazole oral solution, 40 patients) and control group (treated with itraconazole capsule, 38 patients). Oral administration of itraconazole 100 mg twice a day up to 14 d were used in those patients. RESULTS: The total effective rate in treatment group vs control group for 2 wk treatment was 84% and 89%, respectively. There were no significant difference of the total effective rate between two groups (P>0.05), but the candida clearance rate of the treatment group after 2 wk treatment is higher than that of the control group ( P0.05). The adverse reactions rate of two groups was 20% in treatment group when compared to 8% in the control group. No significant adverse reactions were noted. CONCLUSION: Itraconazole oral solution 100 mg twice daily can be effective for treating the patients with oral candidiasis with its characteristic of high efficiency as well as convenient and lower adverse reactions and is one of relatively ideal antifungal agent for oral candidiasis.

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Accession: 012245638

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