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LAMA2 gene analysis in congenital muscular dystrophy: new mutations, prenatal diagnosis, and founder effect



LAMA2 gene analysis in congenital muscular dystrophy: new mutations, prenatal diagnosis, and founder effect



Archives of Neurology 62(10): 1582-1586



Objective: To determine if laminin-alpha 2 deficiency is due to mutations in the LAMA2 gene or secondary to mutations in other congenital muscular dystrophy genes.Methods: We performed molecular analysis of LAMA2, by single-strand conformation polymorphism and sequencing, in 15 patients with undetectable or greatly reduced laminin-alpha 2 expression.

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Accession: 012251544

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PMID: 16216942

DOI: 10.1001/archneur.62.10.1582


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