EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Lens and retina formation require expression of Pitx3 in Xenopus pre-lens ectoderm


Lens and retina formation require expression of Pitx3 in Xenopus pre-lens ectoderm



Developmental Dynamics: An Official Publication of the American Association of Anatomists 234(3): 577-589



ISSN/ISBN: 1058-8388

PMID: 16170783

DOI: 10.1002/dvdy.20540

Pitx3 is expressed in tissues fated to contribute to eye development, namely, neurula stage ectoderm and pre-chordal mesoderm, then presumptive lens ectoderm, placode, and finally lens. Pitx3 overexpression alters lens, optic cup, optic nerve, and diencephalon development. Many of the induced anomalies are attributable to midline deficits; however, as assessed by molecular markers, ectopic Pitx3 appears to temporarily enlarge the lens field. These changes are usually insufficient to generate either ectopic lenses to enlarge the eye that eventually differentiates. Conversely, use of a repressor chimera or of antisense morpholinos alters early expression of marker genes, and later inhibits lens development, thereby abrogating retinal induction. Reciprocal grafting experiments using wild-type and morpholino-treated tissues demonstrate that Pitx3 expression in the presumptive lens ectoderm is required for lens formation. Contradictory to recent assertions that retina can form in the absence of a lens, the expression of Pitx3 in the presumptive lens ectoderm is critical for retina development.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012260345

Download citation: RISBibTeXText

Related references

Xpitx3: A member of the Rieg/Pitx gene family expressed during pituitary and lens formation in Xenopus laevis. Mechanisms of Development 102(1-2): 255-257, 2001

Conservation of gene expression during embryonic lens formation and cornea-lens transdifferentiation in Xenopus laevis. Developmental Dynamics: An Official Publication of the American Association of Anatomists 215(4): 308-318, 1999

Characterizing gene expression during lens formation in Xenopus laevis: evaluating the model for embryonic lens induction. Developmental Dynamics: An Official Publication of the American Association of Anatomists 224(2): 168-185, 2002

Lens formation from cornea in the presence of the old lens in larval Xenopus laevis. Journal of Experimental Zoology 213(1): 9-14, 1980

Transplantation of Xenopus laevis Lens Ectoderm. Csh Protocols 2007: Pdb.Prot4751, 2007

Lens formation from peri corneal epidermis in the presence of the old lens in larval xenopus laevis. Journal of Experimental Zoology 211(3): 303-310, 1980

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes and Development 14(21): 2701-2711, 2000

Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression. Differentiation; Research in Biological Diversity 64(3): 143-149, 1999

Pax-6 and Prox 1 expression during lens regeneration from Cynops iris and Xenopus cornea: evidence for a genetic program common to embryonic lens development. Differentiation; Research in Biological Diversity 65(3): 141-149, 1999

Changes in neural and lens competence in Xenopus ectoderm: evidence for an autonomous developmental timer. Development 112(1): 177-188, 1991

Inhibition of lens-forming potential in non-lens head ectoderm from chicken embryos. Molecular Biology of the Cell 7(Suppl. ): 110A, 1996

Lens induction in the gastrula ectoderm under the effect of adult frog lens epithelium. Doklady Akademii Nauk 343(3): 406-408, 1995

Induction of lens tissue by lens epithelium in frog embryonic ectoderm. Wilhelm Roux's Archives of Developmental Biology 180(3): 213-227, 1976

Induction and competence in morphogenesis: amphibian lens development from non-lens ectoderm, influenced by mercaptoethanol. Oncology 22(4): 290-301, 1968

Specific lens induction in gastrula ectoderm under the influence of lens epithelium in adult frogs. Doklady Biological Sciences 212(1-6): (1974), 1973