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Lethal infection of C3H/HeJ and C3H/SCID mice with an isolate of Leptospira interrogans serovar copenhageni

Nally, J.E.; Fishbein, M.C.; Blanco, D.R.; Lovett, M.A.

Infection and Immunity 73(10): 7014-7017

2005

ISSN/ISBN: 0019-9567
PMID: 16177383
DOI: 10.1128/iai.73.10.7014-7017.2005
Accession: 012261749
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Leptospira interrogans serovar Copenhageni strain RJ16441, a blood isolate from humans with the severe pulmonary form of leptospirosis, has previously been shown to cause fatal pulmonary hemorrhage in guinea pigs and asymptomatic chronic renal tubular colonization with urinary shedding in rats. In this study, RJ16441 caused lethal infection of both C3H/HeJ and C3H/SCID mice, but no hemorrhagic phenomena were observed.

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