Lethal infection of C3H/HeJ and C3H/SCID mice with an isolate of Leptospira interrogans serovar copenhageni
Nally, J.E.; Fishbein, M.C.; Blanco, D.R.; Lovett, M.A.
Infection and Immunity 73(10): 7014-7017
ISSN/ISBN: 0019-9567 PMID: 16177383 DOI: 10.1128/iai.73.10.7014-7017.2005
Leptospira interrogans serovar Copenhageni strain RJ16441, a blood isolate from humans with the severe pulmonary form of leptospirosis, has previously been shown to cause fatal pulmonary hemorrhage in guinea pigs and asymptomatic chronic renal tubular colonization with urinary shedding in rats. In this study, RJ16441 caused lethal infection of both C3H/HeJ and C3H/SCID mice, but no hemorrhagic phenomena were observed.