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Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation

Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation

Investigative Ophthalmology & Visual Science 46(7): 2601-2610

Purpose. Activating ligands of gp130, including leukemia inhibitory factor (LIF), can block differentiation and function of retinal neurons. This study focused on determining whether LIF inhibits differentiation of photoreceptors by altering cell fate or by blocking the expression of essential transcription factors in vivo.Methods. Transgenic mice were generated that had lens-specific expression of the secreted human LIF protein.

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Accession: 012262093

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PMID: 15980254

DOI: 10.1167/iovs.05-0129

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