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Linker for activation of T cells integrates positive and negative signaling in mast cells



Linker for activation of T cells integrates positive and negative signaling in mast cells



Journal of Immunology 173(8): 5086-5094



The transmembrane adapter linker for activation of T cells (LAT) is thought to couple immunoreceptors to intracellular signaling pathways. In mice, its intracytoplasmic domain contains nine tyrosines which, when phosphorylated upon receptor aggregation, recruit Src-homology 2 domain-containing cytosolic enzymes and adapters. The four distal tyrosines are critical for both TCR and FcepsilonRI signaling.

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Accession: 012265810

Download citation: RISBibTeXText

PMID: 15470052

DOI: 10.4049/jimmunol.173.8.5086


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