Section 13
Chapter 12,276

Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survival

Roberts, R.A.; Wright, G.; Rosenwald, A.R.; Jaramillo, M.A.; Grogan, T.M.; Miller, T.P.; Frutiger, Y.; Chan, W.C.; Gascoyne, R.D.; Ott, G.; Muller-Hermelink, H.Konrad.; Staudt, L.M.; Rimsza, L.M.

Blood 108(1): 311-318


ISSN/ISBN: 0006-4971
PMID: 16543468
DOI: 10.1182/blood-2005-11-4742
Accession: 012275254

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Loss of major histocompatibility class It (MHC II) expression in diffuse large B-cell lymphoma (DLBCL) correlates with worse outcome, possibly from decreased immunosurveillance. Primary mediastinal B-cell lymphoma (PMBCL) is a subtype of DLBCL which reportedly has frequent loss of MHC II proteins; however, PMBCL has better survival than DLBCL.

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