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Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles

Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles

International Journal of Biochemistry and Cell Biology 36(7): 1161-1165

ISSN/ISBN: 1357-2725

PMID: 15109563

DOI: 10.1016/s1357-2725(03)00255-3

Since its discovery in the early 1980s, transforming growth factor-beta (TGF-beta) has emerged as a family of growth factors involved in essential physiological processes, including embryonic development, differentiation, tissue repair and cell growth control. Knockout experiments for the three mammalian isoforms of TGF-betas in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis where, in the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface serine/threonine kinase type receptors that activate transcription factors of the Smad family.

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Accession: 012284322

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