Section 13
Chapter 12,289

Mast cell tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells

Kinoshita, M.; Okada, M.; Hara, M.; Furukawa, Y.; Matsumori, A.

Arteriosclerosis Thrombosis and Vascular Biology 25(9): 1858-1863


ISSN/ISBN: 1079-5642
PMID: 15976326
DOI: 10.1161/01.atv.0000174797.71708.97
Accession: 012288322

Objective - Recent studies have highlighted the pathogenetic importance of chronic inflammation in cardiovascular disorders such as congestive heart failure and atherosclerosis. Mast cells release a wide variety of immune mediators that may initiate inflammatory responses, whereas endothelial cells (ECs) play a prominent role in the pathogenesis of cardiovascular diseases by secreting cytokines.

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