+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Molecular basis of intrahepatic cholestasis

Molecular basis of intrahepatic cholestasis

Annals of Medicine 36(8): 606-617

Intrahepatic cholestasis, or impairment of bile flow, is an important manifestation of inherited and acquired liver disease. In recent years, human genetic and molecular studies have identified several genes, the disruption of which results in cholestasis. ATPBB1 (FIC1), ABCB11 (BSEP), and ABCB4 (MDR3) are disrupted in forms of progressive familial intrahepatic cholestasis (PFIC) and related disorders.

(PDF emailed within 0-6 h: $19.90)

Accession: 012318512

Download citation: RISBibTeXText

DOI: 10.1080/07853890410018916

Related references

Molecular basis of intrahepatic cholestasis. Annals of Medicine 36(8): 606-617, 2005

A molecular basis for jaundice in intrahepatic and extrahepatic cholestasis. Hepatology 26(6): 1682-1684, 1997

NR1H4 analysis in patients with progressive familial intrahepatic cholestasis, drug-induced cholestasis or intrahepatic cholestasis of pregnancy unrelated to ATP8B1, ABCB11 and ABCB4 mutations. Clinics and Research in Hepatology and Gastroenterology 36(6): 569-573, 2013

Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: Low GGT cholestasis is a clinical continuum. Journal of Hepatology 36(3): 439-443, March, 2002

Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Practice & Research. Clinical Gastroenterology 24(5): 541-553, 2011

Effects of bezafibrate on dyslipidemia with cholestasis in children with familial intrahepatic cholestasis-1 deficiency manifesting progressive familial intrahepatic cholestasis. Metabolism: Clinical and Experimental 58(1): 48-54, 2008

Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region. Human Molecular Genetics 4(6): 1049-1053, 1995

Chronic intrahepatic cholestasis and related problems--with special reference to 2 cases considered to be intrahepatic cholestasis caused by sulfa drugs. Nihon Rinsho. Japanese Journal of Clinical Medicine 30(9): 1875-1883, 1972

Contribution To The Study Of Intrahepatic Cholestasis. Apropos Of A Case Of Benign Recurring Intrahepatic Cholestasis Studied By Buyssens Reconstruction Method. La Presse Medicale 73: 235-240, 1965

Benign recurrent intrahepatic cholestasis and progressive familial intrahepatic cholestasis linked to PFIC1 Points on a continuum. Hepatology 26(4 PART 2): 384A, 1997

Phenotype-genotype correlations in progressive familial intrahepatic cholestasis and benign recurrent intrahepatic cholestasis. Hepatology 30(4 PART 2): 530A, 1999

Familial benign recurrent intrahepatic cholestasis. Interrelation with intrahepatic cholestasis of pregnancy and from oral contraceptives?. Gastroenterology 71(2): 202-207, 1976

Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy. Sichuan Da Xue Xue Bao. Yi Xue Ban 39(3): 430-433, 2008

Enterocyte inclusions are associated with diarrhea in both genetically documented progressive familial intrahepatic cholestasis, type 1, and intrahepatic cholestasis characterized by coarsely granular Byler bile. Hepatology 32(4 Pt 2): 211A, October, 2000