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Molecular basis of intrahepatic cholestasis



Molecular basis of intrahepatic cholestasis



Annals of Medicine 36(8): 606-617



Intrahepatic cholestasis, or impairment of bile flow, is an important manifestation of inherited and acquired liver disease. In recent years, human genetic and molecular studies have identified several genes, the disruption of which results in cholestasis. ATPBB1 (FIC1), ABCB11 (BSEP), and ABCB4 (MDR3) are disrupted in forms of progressive familial intrahepatic cholestasis (PFIC) and related disorders.

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Accession: 012318512

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DOI: 10.1080/07853890410018916



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