+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Molecular evolutionary characterization of the mussel Mytilus histone multigene family: first record of a tandemly repeated unit of five histone genes containing an H1 subtype with "orphon" features

Molecular evolutionary characterization of the mussel Mytilus histone multigene family: first record of a tandemly repeated unit of five histone genes containing an H1 subtype with "orphon" features

Journal of Molecular Evolution 58(2): 131-144

ISSN/ISBN: 0022-2844

PMID: 15042333

DOI: 10.1007/s00239-003-2531-5

The present work represents the first characterization of a clustered histone repetitive unit containing an H1 gene in a bivalve mollusk. To complete the knowledge on the evolutionary history of the histone multigene family in invertebrates, we undertake its characterization in five mussel Mytilus species, as an extension of our previous work on the H1 gene family. We report the quintet H4-H2B-H2A-H3-H1 as the major organization unit in the genome of Mytilus galloprovincialis with two 5S rRNA genes with interspersed nontranscribed spacer segments linked to the unit, which is not justified by their cotranscription with histone genes. Surprisingly, 3' UTR regions of histone genes show two different mRNA termination signals, a stem-loop and a polyadenylation signal, both related to the evolution of histone gene expression patterns throughout the cell cycle. The clustered H1 histones characterized share essential features with "orphon" H1 genes, suggesting a common evolutionary origin for both histone subtypes which is supported by the reconstructed phylogeny for H1 genes. The characterization of histone genes in four additional Mytilus species revealed the presence of strong purifying selection acting among the members of the family. The chromosomal location of most of the core histone genes studied was identified by FISH close to telomeric regions in M. galloprovincialis. Further analysis on nucleotide variation would be necessary to assess if H1 proteins evolve according to the birth-and-death model of evolution and if the effect of the strong purifying selection maintaining protein homogeneity could account for the homologies detected between clustered and "orphon" variants.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012321505

Download citation: RISBibTeXText

Related references

Molecular and evolutionary analysis of mussel histone genes (Mytilus spp.): possible evidence of an "orphon origin" for H1 histone genes. Journal of Molecular Evolution 55(3): 272-283, 2002

Birth-and-death evolution with strong purifying selection in the histone H1 multigene family and the origin of orphon H1 genes. Molecular Biology and Evolution 21(10): 1992-2003, 2004

Molecular evolution of the nontandemly repeated genes of the histone 3 multigene family. Molecular Biology and Evolution 19(1): 68-75, 2002

Organization, nucleotide sequence, and chromosomal mapping of a tandemly repeated unit containing the four core histone genes and a 5S rRNA gene in an isopod crustacean species. Genome 43(2): 341-345, 2000

The structure of the human histone genes: clustered but not tandemly repeated. Cell 24(3): 661-668, 1981

Histone genes are clustered but not tandemly repeated in the chicken genome. Proceedings of the National Academy of Sciences of the United States of America 78(5): 2856-2860, 1981

Early evolution of histone genes: prevalence of an 'orphon' H1 lineage in protostomes and birth-and-death process in the H2A family. Journal of Molecular Evolution 66(5): 505-518, 2008

Asexuality Associated with Marked Genomic Expansion of Tandemly Repeated rRNA and Histone Genes. Molecular Biology and Evolution 38(9): 3581-3592, 2021

Sea urchin (lytechinus pictus) late-stage histone H3 and H4 genes: characterization and mapping of a clustered but nontandemly linked multigene family. Cell 31(2 Part 1): 383-393, 1982

On the origins of tandemly repeated genes: does histone gene copy number in Drosophila reflect chromosomal location?. Chromosoma 99(2): 118-124, 1990

Mytilus edulis core histone genes are organized in two clusters devoid of linker histone genes. Journal of Molecular Evolution 56(5): 597-606, 2003

Chromosomal organization of the 18S and 5S rRNAs and histone H3 genes in Scarabaeinae coleopterans: insights into the evolutionary dynamics of multigene families and heterochromatin. Bmc Genetics 12: 88, 2011

Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. Nucleic Acids Research 15(7): 2871-2889, 1987

Coordinate replication of members of the multigene family of core and H1 human histone genes. Proceedings of the National Academy of Sciences of the United States of America 81(24): 7723-7727, 1984

The Vertebrate Linker Histones H10, H5, and H1M Are Descendants of Invertebrate "Orphon" Histone H1 Genes. Journal of Molecular Evolution 44(4): 466-467, 1997