EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Multi-scale modeling of the follicle selection process in the ovary



Multi-scale modeling of the follicle selection process in the ovary



Mathematical Biosciences 198(1): 57-79



The biological meaning of follicular development is to free fertilizable oocytes at the time of ovulation. The ovulation rate results from an FSH-dependent follicle selection process. In this paper, we designed a multi-scale model of follicular development, where selection arises from the endocrine feedback between the ovaries and pituitary gland and appeals to control theory concepts. Each ovarian follicle is described through a 2D density function giving an age and maturity-structured description of its cell population. The control intervenes in the velocity, gain and loss terms of the conservation law ruling the changes in the density. The model accounts for the changes in the total cell number, growth fraction and global maturity of both ovulatory and degenerating follicles for various intensities of the selection rate. The different selection process outputs (mono- or poly-ovulation, anovulation) predicted by the model are consistent with physiological knowledge regarding vascularization, pituitary sensitivity to ovarian feedback and treatment with exogenous FSH. (c) 2005 Elsevier Inc. All rights reserved.

(PDF emailed within 0-6 h: $19.90)

Accession: 012331030

Download citation: RISBibTeXText

PMID: 16038949

DOI: 10.1016/j.mbs.2005.05.003



Related references

Integrated, multi-scale modeling for process, parameter and policy research at the river basin scale. Eos, Transactions, American Geophysical Union 85(47, Suppl, 2004

Observations in favor of normal early follicle development and disturbed dominant follicle selection in polycystic ovary syndrome. Gynecological Endocrinology 8(2): 75-82, 1994

Correlation modeling between process condition of sandblasting and surface texture: A multi-scale approach. Scanning 38(3): 191-201, 2015

Follicle selection in the avian ovary. Reproduction in Domestic Animals 47 Suppl 4: 283-287, 2013

Addressing the multi-scale LAPSUS of landscape. Multi-scale landscape process modelling to support sustainable land use: a case study for the Lower Guadalhorce valley South Spain. Addressing the multi scale lapsus of landscape Multi scale landscape process modelling to support sustainable land use: a case study for the Lower Guadalhorce Valley, South Spain: 172 pp., 2002

Multi-scale, multi-resolution brain cancer modeling. Mathematics and Computers in Simulation 79(7): 2021-2035, 2010

Multi-scale, multi-modal neural modeling and simulation. Neural Networks 24(9): 917-917, 2012

SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis. Conference Proceedings 2007: 6649-6652, 2007

Identification of novel candidate genes for follicle selection in the broiler breeder ovary. Bmc Genomics 13: 494-494, 2013

Connectivity Modeling System A probabilistic modeling tool for the multi-scale tracking of biotic and abiotic variability in the ocean. Environmental Modelling & Software 42: 47-54, 2013

Ipsilateral versus contralateral ovary selection of dominant follicle in succeeding cycle. Obstetrics and Gynecology 77(2): 247-249, 1991

A multi-feature and multi-channel univariate selection process for seizure prediction. Clinical Neurophysiology 116(3): 506-516, 2005

Modeling ozone and aerosol formation and transport in the pacific northwest with the community Multi-Scale Air Quality (CMAQ) modeling system. Environmental Science & Technology 40(4): 1286-1299, 2006

The process of atresia and the fate of the discharged follicle in the ovary of Glyplothorax pectin-opterus. Zoologischer Anzeiger, 181: 153-160, 1968

A proposed multi-scale approach with automatic scale selection for image change detection. The Egyptian Journal of Remote Sensing and Space Science 13(1): 0-10, 2010