+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells



Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells



Cellular and Molecular Life Sciences 63(1): 92-99



Beside its pivotal role in reproduction, the pituitary hormone prolactin (PRL) has been attributed an immunomodulatory function. Here we report that cAMP is an important stimulator of PRL transcription in primary human T lymphocytes. Inhibition of both protein kinase A (PKA) and p38 MAPK partially abrogated cAMP-induced PRL expression. In addition, cAMP-induced phosphorylation of p38 was shown to occur independently of PKA and could be mimicked by a methylated cAMP analogue which specifically activates the recently discovered cAMP receptor EPAC (exchange protein directly activated by cAMP). Our findings suggest that cAMP induces PRL expression in T lymphocytes via cooperation of at least two different signaling pathways: a PKA-dependent pathway leading to the phosphorylation of cAMP response element-binding protein, and a PKA-independent pathway leading to p38 phosphorylation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012332309

Download citation: RISBibTeXText

PMID: 16378242

DOI: 10.1007/s00018-005-5433-4


Related references

Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 b-cells. American Journal of Physiology 286(2): 04-E310, 2004

Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells. American Journal of Physiology. Endocrinology and Metabolism 286(2): E304-E310, 2003

Camp-dependent signaling pathways regulate the human histidine decarboxylase promoter through activation of MAPK/ERK-cascades in gastric cancer cells. Gastroenterology 114(4 PART 2): A1149, April 15, 1998

Tu1399 The Bile Acid (Ba), Lithocholic Acid (Lca) Alters Multiple Signaling Cascades in Human T84 Colonic Cells, but Attenuates Forskolin (Fsk) Induced Cl Secretion Only via Interfering With cAmp Production and Basolateral Membrane (Blm) K+ Conductances. Gastroenterology 148(4): S-879, 2015

Conserved cAMP signaling cascades regulate fungal development and virulence. Fems Microbiology Reviews 25(3): 349-364, 2001

Ethanol-induced activation of membrane-initiated cAMP signaling fails to up-regulate PEPCK expression by the regenerating liver. Gastroenterology 110(4 SUPPL ): A1286, 1996

Interaction of signal cascades induced by camp and prolactin in bovine oocyte-cumulus complexes. Tsitologiya: 8, 734-742, 2008

Interaction of signal cascades induced by cAMP and prolactin in bovine oocyte-cumulus complexes. Tsitologiia 50(8): 734-742, 2008

Interaction of signal cascades induced by cAMP and prolactin in bovine oocyte-cumulus complexes. Cell and Tissue Biology 2(5): 472-480, 2008

Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems. American Journal of Physiology. Cell Physiology 289(2): C444-C454, 2005

Prolactin expression is induced in Jurkat T-cells by beta-catenin LEF-1, AP-1 and cAMP. Biochemical and Biophysical Research Communications 354(2): 598-602, 2007

Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells. International Journal of Cancer 122(11): 2437-2445, 2008

Distinct cAMP signaling pathways differentially regulate a2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. American Journal of Physiology 288(1): 9-H76, 2005

Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. American Journal of Physiology Heart and Circulatory Physiology 288(1): H69-H76, 2005

Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology 288(1): H69-H76, 2004