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Mycophenolate mofetil is effective and well tolerated in the treatment of refractory acute and chronic graft-versus-host disease



Mycophenolate mofetil is effective and well tolerated in the treatment of refractory acute and chronic graft-versus-host disease



International Journal of Hematology 83(1): 80-85



We enrolled 11 patients with refractory graft-versus-host disease (GVHD) in a prospective trial evaluating the efficacy of mycophenolate mofetil (MMF). Four (67%) of the 6 patients with acute GVHD and all 5 patients with chronic GVHD responded to MMF. Ten (91%) of the 11 patients were able to decrease steroid use (median decrease, 86%; range, 25%-100%). After a median follow-up of 18 months (range, 1-65 months), 7 patients (64%) remained alive. The adverse events were infectious complications (36%), diarrhea (27%), and neutropenia (18%); the only patient discontinuing MMF did so because of grade 4 neutropenia. This preliminary study suggests that MMF is a well-tolerated agent and has a beneficial effect in the treatment of refractory acute and chronic GVHD.

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Accession: 012337547

Download citation: RISBibTeXText

PMID: 16443558

DOI: 10.1532/IJH97.05111



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