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Neutralizing human antibodies to varicella-zoster virus (VZV) derived from a VZV patient recombinant antibody library

Neutralizing human antibodies to varicella-zoster virus (VZV) derived from a VZV patient recombinant antibody library

Journal of General Virology 85(Pt 12): 3493-3500

ISSN/ISBN: 0022-1317

PMID: 15557222

DOI: 10.1099/vir.0.80406-0

Varicella-zoster virus (VZV), the causative agent of chickenpox and herpes zoster, can be life-threatening in prematurely born children and in children with immune defects or who are under immunosuppressive treatment. Therefore agents for passive immunization, such as VZV-specific immunoglobulin preparations (VZIG) derived from convalescent plasma, are crucial in the prophylaxis of VZV infection. This study describes the isolation of human VZV-neutralizing recombinant antibodies.

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Accession: 012350574

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