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Neutralizing monoclonal antibody against Anthrax lethal factor inhibits intoxication in a mouse model



Neutralizing monoclonal antibody against Anthrax lethal factor inhibits intoxication in a mouse model



Human Antibodies 12(4): 129-135



Anthrax toxin is the dominant virulence factor of Bacillus anthracis; drugs blocking its action could therefore have therapeutic benefit. We report here the production of a neutralizing monoclonal antibody (mAb) against anthrax lethal factor (LF) and the inhibition by the antibody of anthrax lethal toxin (LeTx) formation. The anti-LF monoclonal antibody LF8 neutralized the LeTx challenge both in vitro with macrophage J774A.1 cells and in vivo in nude mice.

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Accession: 012350577

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