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Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux

Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux

Cancer Research 65(2): 516-525

Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic effects of chemotherapeutic agents. It may occur through different mechanisms, but it often correlates with the overexpression of integral membrane transporters, such as P-glycoprotein (Pgp) and MDR-associated proteins (MRPs), with resulting decrease of drug accumulation and cellular death.

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Accession: 012356546

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PMID: 15695394

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