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Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification



Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification



Arteriosclerosis, Thrombosis, and Vascular Biology 25(8): 1629-1633



Objective-Matrix gamma-carboxyglutamic acid (Gla) protein (MGP), a vitamin K-dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease.Methods and Results-Novel conformation-specific antibodies against MGP were used for immunohistochemistry of healthy and sclerotic arteries.

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Accession: 012364154

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PMID: 15961706

DOI: 10.1161/01.atv.0000173313.46222.43


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