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Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A

Zsarnovszky, A.; Le, H.H.; Wang, H-Sheng.; Belcher, S.M.

Endocrinology 146(12): 5388-5396

2005


ISSN/ISBN: 0013-7227
PMID: 16123166
DOI: 10.1210/en.2005-0565
Accession: 012377187

In addition to regulating estrogen receptor-dependent gene expression, 17 beta-estradiol (E-2) can directly influence intracellular signaling. In primary cultured cerebellar neurons, E-2 was previously shown to regulate growth and oncotic cell death via rapid stimulation of ERK1/2 signaling. Here we show that ERK1/2 signaling in the cerebellum of neonatal and mature rats was rapidly responsive to E-2 and during development to the environmental estrogen bisphenol A (BPA).

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