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Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs



Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs



Journal of Applied Physiology 99(5): 1782-1788



Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear. We tested whether DVH existed in ovalbumin ( Ova)-treated guinea pigs, an established animal model of asthma. Twelve guinea pigs were exposed to Ova (1% in saline) or saline aerosol ( control) for 5 min, 5 days/wk, for 2 wk. After completing aerosol exposure, the animals were anesthetized and exposed to systemic hypoxia.

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Accession: 012385602

Download citation: RISBibTeXText

PMID: 16024517

DOI: 10.1152/japplphysiol.00613.2005


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