+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage



PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage



Experimental and Toxicologic Pathology 56(4-5): 291-303



In this study, we evaluated the effect of prostaglandin E2 (PGE2) on renal and hepatic function using an experimental cirrhosis model plus acute liver damage (ALD). Male Wistar rats treated with carbon tetrachloride (CCl4) for 8 weeks were used for the cirrhosis model. Cirrhotic rats were further exposed to an additional acute dose of CCl4 to induce ALD and then treated with PGE2 intramuscularly twice a day for 7 days (200 microg/Kg/day). PGE2 administration started 3 h after the additional dosing of CCl4 and PGE2 effect on hepatorenal function was examined on days 1, 2, 3, and 7. PGE2-treatment ameliorated the decrease in urinary sodium excretion, and normalized serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma renin observed in cirrhotic rats with ALD. In addition, PGE2-treatment decreased mean arterial pressure, glomerular hypercellularity and thickening of the kidney capillary wall, and liver steatosis and cellular necrosis. Also, PGE2 increased the number of regenerative nodules. Finally, PGE2-treatment inhibited the increase in Alpha 1-acid glycoprotein (pAGP), fibrinogen, and Apo A-1 mRNA expression by 83%, 59%, and 77%, respectively. These results suggest that PGE2 administration may decrease the expression of acute phase proteins. In conclusion, PGE2-treatment improved hepatic and renal function and may be useful to down-regulate the acute phase response in cirrhotic rats presenting ALD induced by CCl4.

(PDF emailed within 0-6 h: $19.90)

Accession: 012390996

Download citation: RISBibTeXText

PMID: 15816358

DOI: 10.1016/j.etp.2004.10.003


Related references

Plasma renin activity and kidney damage in response to acute renal ischaemia and ramipril treatment in ovariectomised and uninephrectomised rats. Medical Science Research 25(8): 533-536, 1997

Liver uptake of C14c14 and acute liver damage in the normal, fatty, and cirrhotic mouse liver. Lab Invest 12(8): 861, 1963

Acute liver damage in cirrhotic rats An experimental model of hepatorenal syndrome. Gastroenterology 104(4 SUPPL ): A979, 1993

Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). II. Recovery from the acute, CCl4-induced liver damage. Polish Journal of Occupational Medicine and Environmental Health 6(4): 399-408, 1993

Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). I. Early, acute CCl4-induced liver damage in rabbits. Polish Journal of Occupational Medicine and Environmental Health 6(2): 169-183, 1993

Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats. Amino Acids 16(1): 1-11, 1999

A study on transaminase activity in rabbits with experimental liver damage, with special reference to the influence of injections of ATP preparations on acute liver damage. Sapporo Igaku Zasshi. Sapporo Medical Journal 20: 231-244, 1961

Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats. Experimental and Toxicologic Pathology 58(2-3): 185-195, 2006

Acute carbon tetrachloride hepatotoxicity. IV. Liver and serum enzyme activity during the acute damage phase. Archives of Environmental Health 16(6): 770-776, 1968

Effect of acute liver damage on Ac-globulin activity of plasma. Proc Soc Exptl Biol And Med 67(4): 506-507, 1948

Free amino acids of plasma in the acute phase of experimental necrotic liver damage. Research Communications in Chemical Pathology and Pharmacology 5(2): 403-410, 1973

Thymus alteration in acute chronic and cirrhotic liver damage. Journal of Hepatology 1, 1985

Acute benzo[a]pyrene treatment causes different antioxidant response and DNA damage in liver, lung, brain, stomach and kidney. Heliyon 4(11): E00898, 2018

Changes in plasma enzyme activities and other blood components in response to acute and chronic liver damage in cattle. Research in Veterinary Science 31(1): 1-4, 1981

Free amino acids in liver tissue in the acute phase of experimental necrotic liver damage. Research Communications in Chemical Pathology and Pharmacology 6(2): 473-479, 1973