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Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells



Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells



Biological & Pharmaceutical Bulletin 29(3): 522-526



To investigate the mechanism responsible for the intestinal absorption of a lipophilic organic cation, quinidine, we performed a pharmacokinetic analysis of transcellular transport across Caco-2 cell monolayers grown on a porous membrane. Basolateral-to-apical transport of the drug was almost constant in the concentration range of 100 nM-100 mu M. Transcellular transport was greater in the apical-to-basolateral direction than in the opposite direction.

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Accession: 012408134

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PMID: 16508158

DOI: 10.1248/bpb.29.522


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