+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients



Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients



Progress in Neuro-Psychopharmacology & Biological Psychiatry 30(2): 251-264



Purpose: To evaluate clinical efficacy of clozapine in relation with its plasma level in a group of Chinese patients with treatment-resistant schizophrenia. In addition, the relationship between plasma level and side effects were examined.Method: Fifty-one patients with treatment-resistant schizophrenia were put on a fixed dose of clozapine at 300 mg/day for 6 weeks. Non-responders to week 6 received 500 mg/day in subsequent 6 weeks. Responders to week 6 continued to receive 300 mg/day.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012422610

Download citation: RISBibTeXText

PMID: 16316716

DOI: 10.1016/j.pnpbp.2005.10.008


Related references

Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. American Journal of Psychiatry 152(2): 179-182, 1995

Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. American Journal of Psychiatry 148(2): 231-235, 1991

Monitoring of plasma clozapine levels and its metabolites in refractory schizophrenic patients. Therapeutic Drug Monitoring 18(2): 200-207, 1996

Clinical and neurocognitive effects of clozapine and risperidone in treatment-refractory schizophrenic patients: a prospective study. Journal of Clinical Psychiatry 59(10): 521-527, 1998

Effects of venlafaxine treatment on clozapine plasma levels in schizophrenic patients. Neuropsychobiology 51(4): 173-176, 2005

Fronto-striato-thalamic perfusion and clozapine response in treatment-refractory schizophrenic patients. A 99mTc-HMPAO study. Psychiatry Research 76(1): 51-61, 1997

Clinical outcome and plasma levels of clozapine and norclozapine in drug-resistant schizophrenic patients. Schizophrenia Research 66(2-3): 197-198, 2004

Clozapine plasma levels, ABCB1 haplotype and clinical response to treatment in psychotic patients. 2007

Clozapine plasma levels and dosing strategies in patients with treatment-refractory schizophrenia. Irish Journal of Psychological Medicine 14(3): 85-88, 1997

Neuroleptic-resistant schizophrenic patients treated by clozapine: Clinical evolution, plasma and red blood cell clozapine and desmethylclozapine. Therapie 52(3): 227-232, 1997

Should chronic treatment refractory akathisia be an indication for the use of clozapine in schizophrenic patients?. Journal of Clinical Psychiatry 53(7): 248-251, 1992

Clozapine and metabolites plasma levels in resistant schizophrenic patients. Journal de Pharmacie Clinique 18(3): 244-250, 1999

Gender differences in plasma clozapine levels and its metabolites in schizophrenic patients. Human Psychopharmacology. 12(5): 489-495,.-., 1997

Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biological Psychiatry. 34(10): 702-712, 1993