+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Plasma lipids in Iranians with sickle cell disease: hypocholesterolemia in sickle cell anemia and increase of HDL-cholesterol in sickle cell trait

Plasma lipids in Iranians with sickle cell disease: hypocholesterolemia in sickle cell anemia and increase of HDL-cholesterol in sickle cell trait

Clinica Chimica Acta; International Journal of Clinical Chemistry 365(1-2): 217-220

The metabolism of lipids may be altered in sickle cell anemia and beta-thalassemia patients. Plasma lipids in 24 patients with sickle cell anemia (SS), 15 patients with sickle/beta-thalassemia (ST), 19 individuals with sickle cell trait (AS) and 62 healthy individuals (AA) were measured. Total cholesterol concentrations in both sexes with sickle cell anemia (SS males: 104.7, SS females: 142.7 mg/dl) and sickle/beta-thalassemia (ST males: 116.7, ST females: 137.5 mg/dl) were lower (P<0.05) than AS (AS males: 171.5, AS females: 185.4 mg/dl) and normal individuals (AA males: 173.7, AA females: 183.0 mg/dl). The mean HDL-cholesterol in males with SS (35.6 mg/dl) and ST (40.7 mg/dl) were (P=0.001) lower than AS males (58.9 mg/dl). However, the mean HDL-cholesterol in females with SS (43.2 mg/dl) was lower (P<0.001) than AS females (62.7 mg/dl). The mean LDL-cholesterol of males with SS (53.8 mg/dl) was lower (P<0.01) than AS (89.4 mg/dl) and control males (115.9 mg/dl). Males with ST had a lower (P<0.001) LDL-cholesterol (58.0 mg/dl) compared to control males. In females with SS the LDL-cholesterol (78.3 mg/dl) was lower (P<0.001) than control females (124.3 mg/dl). However, females with ST had lower (P<0.05) LDL-cholesterol (61.6 mg/dl) than AS (101.7 mg/dl) and control females. There was no significant difference in total concentrations of cholesterol and triglycerides between males and females with AS and those with normal hemoglobin. However, the HDL-cholesterol in both genders with AS was higher (P<0.001) than normal subjects. Also, the concentration of LDL-cholesterol in both males and females with AS was lower than control males (P<0.05) and females. Hemolytic stress could be associated with a significant reduction in plasma lipids and lipoproteins. It appears that patients with sickle cell anemia and individuals with sickle cell trait are at a lower risk for coronary artery disease.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012422999

Download citation: RISBibTeXText

PMID: 16185676

DOI: 10.1016/j.cca.2005.08.022

Related references

Frequency distribution of sickle cell anemia, sickle cell trait and sickle/beta-thalassemia among anemic patients in Saudi Arabia. Journal of Natural Science Biology and Medicine 6(Suppl 1): S85-S88, 2015

Novel test method (sickle confirm) to differentiate sickle cell anemia from sickle cell trait for potential use in developing countries. Clinical Laboratory Science 25(1): 26-34, 2012

Effect of hydroxyurea in sickle cell anemia: a clinical trial in children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. Pediatric Hematology and Oncology 16(3): 221-232, 1999

Intriguing prevalence of benin type sickle cell gene on atypical haplotypes in sickle cell beta thalassemia but not in sickle cell anemia in sicily italy. Bank, A (Ed ) Annals Of The New York Academy Of Sciences, Vol 612 Sixth Cooley's Anemia Symposium; New York, New York, Usa, March 13-15, Xiii+590p New York Academy Of Sciences: New York, New York, Usa Illus Maps 502-503, 1990

Red cell indices: differentiation between β-thalassemia trait and iron deficiency anemia and application to sickle-cell disease and sickle-cell thalassemia. Clinical Chemistry and Laboratory Medicine 51(11): 2115-2124, 2013

Sickle cell trait/hereditary persistence of fetal hemoglobin trait. Misdiagnosis as sickle cell anemia by newborn screening. American Journal of Diseases of Children 133(12): 1248-1250, 1979

Studies in sickle cell anemia. VII. Blood volume relationships and the use of a plasma extender in sickle cell disease in childhood: a preliminary report. Pediatrics 18(2): 239-248, 1956

Antiphospholipids and other indicators of coagulation in patients with sickle anemia , HbSC and sickle cell trait disease. Journal of Autoimmunity 15(2): A85, 2000

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait. Expert Review of Hematology 10(12): 1087-1094, 2017

Between black and miscegenated population groups: sickle cell anemia and sickle cell trait in Brazil in the 1930s and 1940s. Historia Ciencias Saude--Manguinhos 18(2): 377-406, 2011

The turnover time of phosphorus in normal, sickle cell trait, and sickle cell anemia blood in vitro as measured with P32 1,2. Science 115(2978): 89-90, 1952

Prevalence of sickle cell trait and sickle cell anemia among newborns in the Federal District, Brazil, 2004 to 2006. Cadernos de Saude Publica 25(1): 188-194, 2009

Studies in sickle-cell anemia: XVII. Sickle-cell trait in the pregnant Negro; Its incidence and relationship to spontaneous abortions. Amer Jour Dis Children 102(4): 480, 1962

Evidence for rapid loss of newly synthesized hemo globin s molecules in sickle cell anemia and sickle cell trait. British Journal of Haematology 35(3): 373-385, 1977

Effect of oxygen tension and of pH on the sickling and mechanical fragility of erythrocytes from patients with sickle cell anemia and the sickle cell trait. Journal of Laboratory and Clinical Medicine 37(5): 789-802, 1951