Section 13
Chapter 12,425

Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model

Ishii, S.; Nagase, T.; Shindou, H.; Takizawa, H.; Ouchi, Y.; Shimizu, T.

Journal of Immunology 172(11): 7095-7102


ISSN/ISBN: 0022-1767
PMID: 15153532
DOI: 10.4049/jimmunol.172.11.7095
Accession: 012424366

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Lipid mediators play an important role in modulating inflammatory responses. Platelet-activating factor (PAF) is a potent proinflammatory phospholipid with eosinophil chemotactic activity in vitro and in vivo. We show in this study that mice deficient in PAF receptor exhibited significantly reduced airway hyperresponsiveness to muscarinic cholinergic stimulation in an asthma model. However, PAF receptor-deficient mice developed an eosinophilic inflammatory response at a comparable level to that of wild-type mice. These results indicate an important role for PAF receptor, downstream of the eosinophilic inflammatory cascade, in regulating airway responsiveness after sensitization and aeroallergen challenge.

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