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Chapter 12,433

Post-translational regulation of circadian transcriptional CLOCK (NPAS2) /BMAL1 complex by CRYPTOCHROMES

Kondratov, R.V.; Kondratova, A.A.; Lee, C.; Gorbacheva, V.Y.; Chernov, M.V.; Antoch, M.P.

Cell Cycle 5(8): 890-895

2006

ISSN/ISBN: 1538-4101
PMID: 16628007
DOI: 10.4161/cc.5.8.2684
Accession: 012432566
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Mammalian CLOCK( NPAS2), BMAL1 and CRYPTOCHROMEs are core components of the circadian oscillatory mechanism. The active CLOCK/ BMAL1 or NPAS2/ BMAL1 complexes regulate expression of numerous genes including two Cryptochromes. The products of these genes, CRY1 and CRY2, in turn repress CLOCK/ BMAL1 transcriptional activity by an unknown mechanism.

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