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Preparation and spectral investigation on inclusion complex of beta-cyclodextrin with rutin



Preparation and spectral investigation on inclusion complex of beta-cyclodextrin with rutin



Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 59(14): 3421-3429



Solid inclusion complex of rutin with beta-cyclodextrin (beta-CD) was prepared by coprecipitate method. The formation of inclusion complex was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction. The formation constant was obtained by steady-state fluorescence measurements and the result suggested the complex preferred 1:1 (rutin:CD) stoichiometry. Furthermore, the spatial configuration of the complex has been proposed based on NMR and molecular modeling.

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Accession: 012443512

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PMID: 14607238


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