+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder

Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder

Psychoneuroendocrinology 29(9): 1129-1137

Although evidence suggests that major depressive disorder (MDD) is associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, research on basal HPA axis hormone levels in MDD patients has been inconclusive. Definitive characterization of basal cortisol and adrenocorticotropin (ACTH) secretion may be important for understanding the pathophysiology of this disorder. In recent years, a new approach to the analysis of basal hormone secretion has been developed involving the approximate entropy (ApEn) statistic, which represents the degree of disorderliness or serial irregularity in a time series of hormone levels. ApEn has been shown to reflect the degree of coordination in integrated network systems and has provided new insights into the pathophysiology of a number of endocrine conditions. In the study reported here, 15 medication-free men with MDD and 15 healthy control men were admitted to a General Clinical Research Center and had blood sampled for cortisol and ACTH determinations every hour over a 24-h period. The cortisol and ACTH time series were characterized with a cosinor analysis and with analysis of ApEn. Depressed patients and control subjects did not differ significantly on any parameter derived from the cosinor analysis or on several other standard indices of basal hormone secretion. However, the depressed men had significantly increased cortisol ApEn and significantly decreased ACTH ApEn compared with the healthy subjects. The ApEn findings suggest a loss of regulatory control over cortisol secretion, and possibly increased cortisol feedback on the pituitary in the depressed patients. Together, these results are most consistent with a primary abnormality of the adrenal gland and suggest that further investigation of adrenal gland physiology may be informative for the pathophysiology of depression.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012452152

Download citation: RISBibTeXText

PMID: 15219636

DOI: 10.1016/j.psyneuen.2004.01.004

Related references

Adrenocorticotropin and cortisol response to lysine vasopressin in relation to the outcome of the dexamethasone suppression test in major depressive disorder. Acta Psychiatrica Scandinavica 77(4): 404-410, 1988

Cortisol secretion in adolescents with major depressive disorder. Acta Psychiatrica Scandinavica 80(1): 18-26, 1989

Cortisol secretion in prepubertal children with major depressive disorder. Episode and recovery. Archives of General Psychiatry 46(9): 801-809, 1989

The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness. Journal of Clinical Endocrinology and Metabolism 61(3): 429-438, 1985

Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder. Biological Psychiatry 59(7): 667-671, 2005

Plasma pattern of adrenocorticotropin and cortisol during electroconvulsive therapy in patients with major depressive illness. Acta Psychiatrica Scandinavica 70(4): 361-369, 1984

24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment. Journal of Clinical Endocrinology and Metabolism 65(1): 141-152, 1987

Depressive rumination alters cortisol decline in Major Depressive Disorder. Biological Psychology 100: 50-55, 2015

Delta sleep inducing peptide response to human corticotropin releasing hormone chr in major depressive disorder comparison with crh induced corticotropin and cortisol secretion. Biological Psychiatry 24(2): 162-172, 1988

Effects of cortisol on cognition in major depressive disorder, posttraumatic stress disorder and borderline personality disorder - 2014 Curt Richter Award Winner. Psychoneuroendocrinology 51: 282-295, 2015

Hypothalamic-pituitary-adrenal axis activity in panic disorder: Effects of alprazolam on 24 h secretion of adrenocorticotropin and cortisol. Journal of Psychiatric Research 30(2): 79-93, 1996

Major depressive disorder, generalised anxiety disorder, and their comorbidity: associations with cortisol in the Vietnam Experience Study. Psychoneuroendocrinology 36(5): 682-690, 2011

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex in depressive episodes of patients with major depressive disorder, bipolar disorder I, and major depressive with alcohol use disorders. Neuroscience Letters 671: 128-132, 2018

C-reactive protein and cortisol in drug-naïve patients with short-illness-duration first episode major depressive disorder: possible role of cortisol immunomodulatory action at early stage of the disease. Journal of Affective Disorders 152-154: 534-537, 2014

Comparison of the cortisol suppression index and the DST within major depressive disorder. Acta Psychiatrica Scandinavica 76(5): 579-582, 1987