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Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis



Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis



Journal of Neurochemistry 95(5): 1461-1471



Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons. We tested the hypothesis that proteomic analysis will identify protein biomarkers that provide insight into disease pathogenesis and are diagnostically useful. To identify ALS specific biomarkers, we compared the proteomic profile of cerebrospinal fluid (CSF) from ALS and control subjects using surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF-MS).

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Accession: 012465358

Download citation: RISBibTeXText

PMID: 16313519

DOI: 10.1111/j.1471-4159.2005.03478.x


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