+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Proton therapy for head and neck malignancies at Tsukuba



Proton therapy for head and neck malignancies at Tsukuba



Strahlentherapie und Onkologie 180(2): 96-101



Purpose: To evaluate the effectiveness and feasibility of proton therapy for head and neck cancers. Patients and Methods: From 1983 to 2000, 33 patients with head and neck malignancies but no history of surgical resection were treated with 250-MeV protons with or without X-ray irradiation. This study retrospectively evaluated local control, survival, and treatment sequelae of these patients. The median total target dose using protons with or without X-rays was 76 Gy (range: 42-99 Gy) and the median proton dose per fraction 2.8 Gy (range: 1.5-6.0 Gy). Results: Overall 5-year survival and Local control rates were 44% and 74%, respectively. One (3%) and six patients (18%) suffered from treatment-related acute and Late toxicity >grade 3 (RTOG/EORTC acute and Late radiation morbidity scoring criteria). One patient with a history of radiotherapy suffered from acute toxicity >grade 3. Conclusion: Proton therapy appeared to offer high Local control rates with few toxicities relative to conventional radiotherapy. However, late toxicity was seen in areas where large radiation doses had been given.

(PDF emailed within 0-6 h: $19.90)

Accession: 012465906

Download citation: RISBibTeXText

PMID: 14762662

DOI: 10.1007/s00066-004-1132-6


Related references

Proton beam radiation therapy for head and neck malignancies. Current Oncology Reports 12(3): 202-207, 2010

Spot-scanning beam proton therapy vs intensity-modulated radiation therapy for ipsilateral head and neck malignancies: a treatment planning comparison. Medical Dosimetry 38(4): 390-394, 2014

Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database. Orl; Journal for Oto-Rhino-Laryngology and Its Related Specialties 78(2): 61-69, 2016

Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort. RadioTherapy and Oncology, 2016

Quantitative assessment of anatomical change using a virtual proton depth radiograph for adaptive head and neck proton therapy. Journal of Applied Clinical Medical Physics 17(2): 5819-5819, 2016

Unilateral and bilateral neck SIB for head and neck cancer patients : Intensity-modulated proton therapy, tomotherapy, and RapidArc. Strahlentherapie und Onkologie 192(4): 232-239, 2016

Head and neck cancers. III. The role of proton therapy in treatment of head and neck cancers. Gan to Kagaku Ryoho. Cancer & ChemoTherapy 36(7): 1098-1100, 2009

Effect of radiation therapy and chemo therapy on endocrine function in children with head and neck malignancies. Clinical Research 26(3): 302A, 1978

Combination therapy for head and neck malignancies radiation therapy. Otologia Fukuoka 15(4): 274-283, 1970

Principles of therapy with fission neutrons and boron neutron capture therapy for radioresistant head-neck malignancies. Laryngo- Rhino- Otologie 69(8): 433-436, 1990

Photodynamic therapy for cutaneous malignancies of the head and neck. Otolaryngologic Clinics of North America 26(2): 311-318, 1993

RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba. Journal of Radiation Research 55(5): 1028-1032, 2015

Osteoradionecrosis associated with definitive radiation therapy for head and neck malignancies. Journal of Prosthetic Dentistry 49(5): 675-679, 1983

Proton therapy for head neck cancer. Oral Oncology 51(2): E10-E12, 2015