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Proton therapy for head and neck malignancies at Tsukuba

Proton therapy for head and neck malignancies at Tsukuba

Strahlentherapie und Onkologie 180(2): 96-101

Purpose: To evaluate the effectiveness and feasibility of proton therapy for head and neck cancers. Patients and Methods: From 1983 to 2000, 33 patients with head and neck malignancies but no history of surgical resection were treated with 250-MeV protons with or without X-ray irradiation. This study retrospectively evaluated local control, survival, and treatment sequelae of these patients. The median total target dose using protons with or without X-rays was 76 Gy (range: 42-99 Gy) and the median proton dose per fraction 2.8 Gy (range: 1.5-6.0 Gy). Results: Overall 5-year survival and Local control rates were 44% and 74%, respectively. One (3%) and six patients (18%) suffered from treatment-related acute and Late toxicity >grade 3 (RTOG/EORTC acute and Late radiation morbidity scoring criteria). One patient with a history of radiotherapy suffered from acute toxicity >grade 3. Conclusion: Proton therapy appeared to offer high Local control rates with few toxicities relative to conventional radiotherapy. However, late toxicity was seen in areas where large radiation doses had been given.

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Accession: 012465906

Download citation: RISBibTeXText

PMID: 14762662

DOI: 10.1007/s00066-004-1132-6

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